De moribus artificum diatriba
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De Morbis Artificum Diatriba (Diseases of Workers), first published in 1700, was written by Italian physician Bernardino Ramazzini. In it, Ramazinni described the health of flax carders who came from Southern France to work near Italy’s Po River. After flax was macerated in autumn, carders were forced to work indoors while treating flax fibers coated in dust. Without sufficient ventilation, they inhaled copious amounts of hazardous particles, causing them to develop severe respiratory diseases. Ramazinni recommended broths and clarified juices made from mallow, violets, and endive or a diet of milk for treatment.